--- title: "Amlodipine: Uses & Side Effects | HealthAnswers" description: "Amlodipine is a calcium channel blocker that relaxes blood vessels to treat high blood pressure and angina, sometimes causing ankle swelling." url: https://healthanswers.co.uk/treatments/amlodipine/ robots: noindex --- # Amlodipine: Uses & Side Effects | HealthAnswers Treatments Amlodipine is a calcium channel blocker that relaxes blood vessels to treat high blood pressure and angina, sometimes causing ankle swelling. Written by HealthAnswers editorial team Medically reviewed by [HealthAnswers UK doctor review panel](https://healthanswers.co.uk/our-doctors/) Reviewed 3 July 2026 ## Quick answer What is amlodipine used for? Amlodipine is a calcium channel blocker medicine that relaxes blood vessels, lowering blood pressure and helping to treat angina. Ankle swelling is a common side effect, which is often manageable or can be improved by switching drugs. It is taken once daily, and large amounts of grapefruit can slightly increase the levels of amlodipine in the body. ## Who is this page for? This page is for people in the UK who want a plain-English overview of Amlodipine, including when to seek help and what NHS care usually involves. It explains general information, not what is wrong with you personally. ## Who should skip this page? Skip this page if you need a diagnosis, a prescription, or emergency care. It cannot replace a GP, pharmacist, NHS 111 or 999. If you are in immediate danger, call 999; for urgent advice that is not life-threatening, call 111 in England, Scotland or Wales, or use your GP out-of-hours service in Northern Ireland. On this page 4 sections ## Key facts about amlodipine - Amlodipine belongs to the dihydropyridine group of calcium channel blockers. - It is taken once daily because it has a long-lasting action. - Ankle swelling is common and may need a dose or drug change. - Flushing and headache can occur, usually when treatment starts. - Amlodipine is safe for many people with asthma, unlike beta-blockers. ## How amlodipine works Amlodipine works by widening blood vessels, which reduces the resistance the heart has to pump against and lowers blood pressure as a result. It also widens the coronary arteries that supply the heart itself, which helps relieve the chest pain of angina. ## Dosing of amlodipine Treatment usually starts at a low dose, which can be increased if needed up to a higher maximum dose. Elderly patients or those with liver problems are usually started on a lower dose, since they may be more sensitive to the medicine’s effects. ## Side effects of amlodipine The most common side effects are swelling of the ankles, flushing and palpitations. Overgrowth of the gums is a rare side effect that some people experience. ## Alternatives to amlodipine Other options include different calcium channel blockers, thiazide diuretics and ACE inhibitors, chosen according to NICE guidance. The right choice depends on how well an individual tolerates each medicine and their other health conditions. ## ! Important safety information for amlodipine Your GP manages your blood pressure treatment. Report severe swelling or chest pain to them. Call **111** for urgent advice when you are unsure what to do. ## Common questions about amlodipine How can I fix ankle swelling caused by amlodipine? Ankle swelling can often be improved by reducing the dose, adding an ACE inhibitor, or switching to an alternative medicine. Discuss the best option for you with your GP rather than stopping treatment yourself. Should I take amlodipine in the morning or evening? Amlodipine can be taken either in the morning or the evening, as long as you take it at a consistent time each day. Some people choose to take it in the evening to help with the timing of symptoms. Can I eat grapefruit while taking amlodipine? Large amounts of grapefruit may increase the effect of amlodipine, so moderation is advised. Ask your GP or pharmacist if you are unsure how much is safe for you. Can amlodipine be taken with ramipril? Yes, amlodipine and ramipril are often combined because they work by complementary mechanisms to lower blood pressure. Your GP will monitor your blood pressure and kidney function while you take both. ## Sources - [NHS — Amlodipine](https://www.nhs.uk/medicines/amlodipine) - [NHS — Angina](https://www.nhs.uk/conditions/angina)